įrom 2017 to 2020, UC Davis worked with neurotechnology company Neuralink to test brain-machine interfaces on monkeys. It has been suggested that these monkeys could have been infected at CNPRC by captive Sooty Mangabey. Evidence from the full length sequences has shown formation of a distinct cluster of SIVmac (the SIV strain that infect the old world monkeys in Asia) within HIV-2 and SIVmac phylogeny. There is a growing evidence of the contribution of CNPRC to the origins of simian immunodeficiency virus (SIV). The research center was the site of this outbreak in what is being considered the first known case of an adenovirus jumping from monkeys to humans. In November 2016, the USDA reported that the CNPRC had improperly stored food for non-human primates. One macaque sustained significant injuries and was euthanized. The two macaques fought and were both injured. In August 2016, CNPRC staff failed to secure a divider door between two non-compatible macaques. Staff tranquilized the macaque and later euthanized it. In June 2016, a macaque escaped its transport enclosure. In March 2016, a macaque escaped through an enclosure door which staff had failed to secure and subsequently broke both of its legs. The USDA reported that staff is required to check restraints every 15 minutes but it was not clear if the restraints had been checked appropriately. The macaque chewed through the tape restraining his upper body which left his legs taped to the board, which caused his leg to be broken. In August 2014, a male macaque was left on a restrain board while receiving intravenous fluid. In May 2014, the USDA reported that a protocol for non-human primates contained an incomplete description of a surgical procedure to implant medical devices into the animals. According to the center's director, “To abandon primate research now would be the biggest hindrance to…medicine" claiming that the animals are needed for the development of new treatments for illnesses, a claim critics of the center dispute. The university has defended their care of the animals and the use of monkeys in medical experimentation. Critics of the center - who have called for the laboratory to be closed- say that the animals are treated poorly, subjected to cruel experiments and that more than 2,000 monkeys are kept in small indoor cages for their entire lives. Federal inspectors have also noted that as many as 50 monkeys were at times able to escape their enclosures. In 2004 the center was fined by the USDA after seven monkeys died after the building overheated. The center was cited by the USDA for AWA violations for failing to provide veterinary care to 19 monkeys who subsequently died between 20. In 2013 a monkey was crushed by his cage door and in 2011 another monkey accidentally strangled himself with a bungee cord left in his cage. Only four of the 23 sick monkeys survived the illness. In 2009 an outbreak of a monkey-killing cold virus identified as an adenovirus infected both monkeys and humans, with the sickness killing about a third of the 65 titi monkeys there. The California NPRC has been criticized for a number of issues related to its care of monkeys including several violations of the Animal Welfare Act (AWA) that have resulted in the deaths of over a dozen animals in recent years. Furthermore, the Center provides resources to elementary science teachers to promote biology, particularly primate biology and behavior, instruction. Children and their teachers learn some basics of primate biology, and about some of the primate-based biomedical research that is performed at the center. They invite local elementary school students to learn about the research and animals through a standardized two-hour program. Īs with most federally funded research institutions, CNPRC provides educational outreach programs to the local community. Similarly, the Center aids off-site researchers with veterinary services from in-house professionals. Through their Affiliate and Pilot Research program, CNPRC supports visiting scientists by providing access to facilities and equipment. The center's research units are focused on four primary topics: Brain, mind, and behavior infectious diseases reproductive sciences and regenerative medicine and respiratory diseases. Scientists using the center's facilities produce numerous papers annually detailing their investigations into human health issues.
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